Nuclear transcription factor kB (NF-kB) activity in lymphocyte populations in children with Wilson-Konovalov disease

Nuclear factor (NF)-kB proteins: therapeutic targets*

N uclear factor (NF)-kB is a key player in the control of both innate and adaptive immunity. NF-kB proteins are present in the cytoplasm in association with inhibitory proteins called inhibitors of kB (IkBs). On activation by a large plethora of inducers, the IkB proteins are phosphorylated, ubiquitinated, and subsequently degraded in the proteasomes. Degradation of IkBs allows translocation of...

Induction of Heme Oxygenase -1 By Lipocalin 2 Mediated By Nf-Kb Transcription Factor

Purpose: Effect of lipocalin 2 on the expression of heme oxygenase I , II and NF-kB transcription factor was the purpose of this survey. Materials and Methods: Lcn2 was cloned to pcDNA3.1 plasmid by using genetic engineering method. The recombinant vector was transfected to CHO and HEK293T to establish stable cell expressing lipocalin 2. The presence of lipocalin 2 gene in these cells was confi...

The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-kB To Dampen NF-kB–Stimulated Gene Transcription

Hypoxia-Induced Endothelial Apoptosis Through Nuclear Factor-kB (NF-kB)–Mediated bcl-2 Suppression In Vivo Evidence of the Importance of NF-kB in Endothelial Cell Regulation

The transcription factor nuclear factor-kB (NF-kB) plays a pivotal role in the coordinated transactivation of cytokine and adhesion molecule genes involved in endothelial activation. Although recent reports have documented the contribution of NF-kB to apoptosis, it is still controversial. Especially, the role of NF-kB in endothelial apoptosis is largely unknown. Hypoxia significantly induced hu...

Human Cytomegalovirus Upregulates NF-kB Activity by Transactivating the NF-kB p105/p50 and p65 Promoters

During human cytomegalovirus (HCMV) infection, a series of regulated events take place following virus binding and entry into the cell, including the upregulation of cellular transcription factors, such as NF-kB, which play an essential role in the viral life cycle. We show here that NF-kB message is induced during HCMV infection and that the induction is biphasic, suggesting an initial inducti...